Built in 1963 and with the experience of using British made 8-inch howitzers during the First World War, the American-made weapon would give general support to troops in the field, counter enemy guns and suppress air defenses. It would see service in the Vietnam War as well as the Persian Gulf War as both the United States and the British armies had the weapon in their arsenal. However, after the Persian Gulf, the weapon was retired from service as advances in technology made 155mm howitzers more effective in combat.

Like many other weapons it had in its inventory, the United States military exported the M110 to many different nations, with Japan being among them. When Godzilla re-appeared in 1984, the M110A2s went into action as the Japanese Self Defense Forces attempted to stop Godzilla from reaching Tokyo. Confronting the king of the monsters in Tokyo Bay, the M110A2s put up a spirited defense but were eventually destroyed with Godzilla incinerated the entire line of ground forces opposing him from the shore with a long blast of his atomic breath.

They would next see action when Godzilla returned in 1989. While not engaging Godzilla at Lake Ashino as he battled the genetically engineered plant monster Biollante, they would see action near Wakasa Bay as the JSDF attempted to lure an ANEB infected Godzilla into range of the M 6000 TCS system. As before, Godzilla destroyed a large number of them with his atomic breath.

When a mysterious UFO landed in Japan in 1992, the M110A2s moved out along with other armored fighting vehicles of the JSDF to surround the mysterious spaceship and perhaps attack it if things got out of control. Fortunately, the spaceship's occupants, who were humans from the future, appeared outside the ship in the form of holograms and defused the situation for the moment.